Toronto will look to sweep Arizona in Wednesday's series finale at Chase Field.
Taking the first two games of the three-game set, the Blue Jays have wreaked havoc with the D-backs' chances at grabbing the final Wild Card spot.
The D-backs have dropped five of their past six decisions, dropping from five games back to eight over that span.
They will turn to young starter Randall Delgado to try to break their recent funk.
Delgado had been having a tough August, with an ERA of 6.00, before switching to prescription glasses on the mound for his past two starts. In those outings, he allowed a combined four earned runs over 13 innings for a 2.77 ERA.
That includes allowing just a single run on three hits and two walks with three strikeouts in his most recent start. Unfortunately, a first-inning run was all the Giants needed, dropping Delgado's record to 4-5.
"He threw like Randall throws," Gibson said. "He had great control, had them off-balance and his location was pretty damn good."
Delgado will be forced to deal with Blue Jays first baseman Edwin Encarnacion, who made history in Tuesday's 10-4 victory. Encarnacion hit an eighth-inning home run off of Will Harris, marking the fifth straight game the Toronto slugger has cleared the fences at Chase Field.
Encarnacion became the only player to homer in five straight games at Chase Field, with the first three dating back to the Blue Jays' most previous trip to Arizona in 2010. He now has seven home runs and 11 RBIs in his last five games at Chase Field.
Mark Buehrle will be on the mound for the Blue Jays, and he has been the club's most consistent starter this season, especially recently.
The veteran left-hander is 6-1 with a 2.14 ERA over his past nine starts, including seven scoreless innings vs. the Royals in his last outing.
"[He has] so many different weapons," Blue Jays catcher J.P. Arencibia said afterward. "He mixes up sinker, cutter, changeup, curveball, in-out, up-down. He really commands the entire zone. It's impressive to see when he does."
Blue Jays: Toronto adds four arms to bullpen
Toronto made sure the bullpen would never be overworked again this season as the club took full advantage of September's expanded rosters.
The Blue Jays called up four pitchers and a catcher and will have at least a 13-man bullpen for the remainder of the season.
Kyle Drabek, Ricky Romero, Jeremy Jeffress, and Luis Perez were the four arms who were added to the club's roster, with Triple-A Buffalo catcher Mike Nickeas rounding out the callups.
With the addition of Romero and Drabek, the Blue Jays added two starters to their stable of arms, although whether they start is still up in the air.
"They'll pitch, we're not exactly sure what role they'll be in, though," manager John Gibbons said. "Ricky just pitched Sunday, so he's off a couple more days anyways. Drabek threw Friday, so he can't throw until tomorrow. We've got plenty of arms down there. We'll make sure they get work, but the game will dictate that."
It marks a return of sorts for both Drabek and Romero. Drabek has been absent the past 14 months after undergoing Tommy John surgery, while Romero has been stuck in the Minors trying to re-learn his craft.
Both of them were in the club's rotation in 2012, with Romero serving as the Blue Jays' ace.
D-backs: Gibson shows frustration after Monday's loss
The usually stoic and even-keeled Kirk Gibson could not hide his emotions after Monday's 4-1 loss to the Blue Jays.
Gibson's D-backs has failed to generate much offense at home the previous five games, scoring just 11 runs and emerging victorious in just one of those contests.
"The offense on this homestand has not been good," Gibson said. "You'd have to ask them; I'm not sure why. Everybody isn't Cy Young, and sometimes you've got to beat Cy Young. You've got to figure out a way to do it. That part's disappointing."
Monday's comments were a rare display for the Arizona skipper but came on the heel of an afternoon that saw the Blue Jays turn four double plays.
"They still may beat you, but you need to maybe make them work a little differently," Gibson said. "You have to have more confidence in waiting them out for better pitches, specifically the double plays."
"[Gerardo] Parra pulled a first-pitch ground ball on the outside part of the plate," Gibson said. "That's what they wanted him to do. That's frustrating. Wil Nieves did the same. Sometimes you've just got to try and extend them, get some pitches on their arm and try and get them to start making mistakes. We got pressure on him, and they took him out right away. I was a little frustrated. I usually hold it in, but I'm good to go today."
• Toronto's victory Tuesday against the D-backs ensured a winning record in Interleague Play for only the fourth time in franchise history. The Blue Jays last completed the feat in 2007, and they head into their Interleague finale with an 11-8 record.
• The D-backs are 29-23 in Interleague since 2011, and they entered the series with the Blue Jays with the second-best National League record, with only the Pirates sporting a better record at 30-20.
• Since 2012 the Blue Jays lead the Majors with 53 home runs in Interleague Play.