The Dodgers come to Chase Field for a three-game series hobbled by injuries. Matt Kemp, Jerry Hairston Jr., Juan Uribe, Juan Rivera and Mark Ellis all hit the disabled list in the last two weeks for the visitors.
D-backs rookie left-hander Patrick Corbin will be the first hoping to take advantage of the weakened lineup when he takes the mound for the opener.
After the best start of his brief career on May 11 against the Giants, when he allowed just one run on three hits over seven innings, the 22-year-old Corbin struggled in his last outing on Wednesday.
Corbin lasted six innings, but gave up six earned runs on nine hits in a 6-1 loss to the Rockies.
While Colorado did hit some balls hard off Corbin, it also benefited from a two-run infield single by Jamie Moyer in the fourth that gave the Rockies a 5-0 lead.
"I thought I made some good pitches and they found some spots," Corbin said after the game. "That's kind of how baseball goes. I felt like I got ahead of some guys and made some decent pitches and a couple got through."
For the Dodgers, Chris Capuano will be looking to bounce back from his first loss of the season against the D-backs.
The 33-year-old entered Wednesday's start in San Diego at 5-0, but surrendered four runs (three earned) over 6 1/3 innings in a 4-2 loss.
"I wasn't attacking like earlier in the game," Capuano said afterwards. "I sort of lost focus and tried to get a certain outcome instead of just getting the ball down. It wasn't the right focus."
Fortunately for Capuano and the Dodgers, the club has been able to thrive despite all of their banged-up teammates.
"We're still pretty early, even though it's not like it's the first two weeks or nothing," Dodgers manager Don Mattingly said. "There's still lots of baseball to be played. There's still 120 games or something. That's a lot of ball.
"Obviously, it's positive for us that we've been able to sustain and we've been able to survive."
Dodgers: Ellis has surgery
Mark Ellis underwent an "urgent" procedure on his left leg Saturday and will be sidelined at least six weeks, trainer Sue Falsone said after the club's win over the Cardinals.
Ellis exited Friday's game when he was upended on a hard slide by St. Louis second baseman Tyler Greene.
"We sent him over to the hospital," Falsone said. "They did some different testing. Basically what they do is test the pressures inside the leg. He had pressure in his leg to the point where he needed a fasciotomy."
Ellis was hitting .273 this season with two homers and an on-base clip of .373.
D-backs: Young easing his way back
Interleague Play is providing D-backs manager Kirk Gibson with an opportunity to ease outfielder Chris Young back into the swing of things.
Young injured his shoulder in April and came off a month-long stay on the disabled list for the series opener against the Royals on Friday. He served as the designated hitter in Friday's game, and played center field on Saturday. On Sunday, Young went 0-for-4 as the DH in the D-backs' 2-0 victory.
"It kind of worked out because we have the DH here [in Kansas City]. Because he's been playing the outfield in the Minor Leagues, he's coming along fine," Gibson said.
When the D-backs play the Dodgers, they won't have the luxury of the DH and will have to make a decision on who to start among four outfielders.
Capuano is 1-4 with a 4.14 ERA in seven career games (six starts) against the D-backs. He made one start against Arizona in 2011, allowing four runs over six innings in a loss.
Daniel Hudson is scheduled to make a rehab start for Triple-A Reno on Monday night.